The expressions of inflammatory factors and tissue inhibitor of matrix metalloproteinase-2 in human chronic periodontitis with type 2 diabetes mellitus
신동석, 박진우, 서조영, 이재목,
소속 상세정보
신동석 ( Shin Dong-Seok ) - 경북대학교 치의학전문대학원 치주과학교실
박진우 ( Park Jin-Woo ) - 경북대학교 치의학전문대학원 치주과학교실
서조영 ( Suh Jo-Young ) - 경북대학교 치의학전문대학원 치주과학교실
이재목 ( Lee Jae-Mok ) - 경북대학교 치의학전문대학원 치주과학교실
KMID : 0363020100400010033
Abstract
Purpose:The purpose of this study was to observe and quantify the expression of interleukin-4 (IL-4), interferon-γ (IFN-γ), and tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) in the gingival tissue of patients with type 2 diabetes mellitus (DM) and healthy adults with chronic periodontitis.
ethods:Twelve patients with type 2 DM and chronic periodontitis (Group 3), twelve patients with chronic periodontitis (Group 2), and twelve healthy individuals (Group 1) were included in the study. Clinical criteria of gingival (sulcus bleeding index value, probing depths) and radiographic evidences of bone resorption were divided into three groups. The concentrations of cytokines were determined by a western blot analysis and compared using one-way ANOVA followed by Tukey’s test.
Results:The expression levels of IFN-γ and TIMP-2 showed an increasing tendency in Groups 2 and 3 when compared to Group 1. On the other hand, the expression of IL-4 was highest in Group 1.
Conclusions:The findings suggest that IFN-γ and TIMP-2 may be involved in the periodontal inflammation associated with type 2 DM. IL-4 may be involved in the retrogression of the periodontal inflammation associated with type 2 DM.
키워드
Chronic periodontitis;Tissue inhibitor of metalloproteinases;Type 2 diabetes mellitus
원문 및 링크아웃 정보
등재저널 정보